Profile of the GRK 1482

Nutrition and gut luminal factors such as microbes are most likely prime environmental factors that not only determine a healthy gut phenotype but also shape a disease-conditioning situation in the susceptible host. Although substantial progress has been made in identifying genetic variations associated with IBD, obesity and type-2 diabetes, striking evidence has been generated in both immune-mediated and metabolic disorders demonstrating that environmental triggers are the driving force for chronic disease development.

 

 

Mechanisms that determine the transition from normal functions in healthy subjects towards disease-relevant situations are critical to understand in the life-long exposure to nutritional factors and commensal microbes. Specifically the intestinal microbiome, with an enormous microbial density outnumbering the cellularity of the human body by 10 times and the complexity of the human genome by 150 times, provides a striking degree of genetic variation and comes more and more into focus of metabolic functions and metabolic disorders. There can be no doubt that the intestinal interface as a barrier and communication organ plays a pivotal role in this interaction. Bacteria are crucial determinants in chronic inflammatory disorders and IBD serves as a paradigm to study the principles of microbe-host interactions in the gut. The potential for future development and innovation lies within the interaction of disease categories with the gut interface as a potential target.

 

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