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GRK 1482 Jahrbuch 2011-2014

JUNIOR PRINCIPAL INVESTIGATORS Page 28 | GRK Progress Report 2011-2014 Education / Degrees 1979 - 1986 Diploma in Biology, Ruprecht-Karls-Universität Heidelberg, Germany 1991 PhD in Biology, Ruprecht-Karls-Universität Heidelberg, Germany Positions held 1991 - 1992 Research Associate, Department of Tumor- and Cell Biology, German Cancer Research Center, Heidelberg, Germany 1992 - 1994 DFG-Research Fellow, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, USA 1994 - 1997 Research Associate, Howard Hughes Medical Institute at Massachusetts Institute of Technology, Cambridge, USA 1997 - 2003 Group leader, Max-Planck-Institute for Biochemistry, Martinsried, Germany 2004 to date Group leader, Nutritional Medicine, Technische Universität München, Freising, Germany 2007 to 2012 Research Coordinator of the ZIEL-PhD Group-Epigenetics, Imprinting and Nutrition, Technische Universität München, Freising, Germany Research Interests and Achievements The group of Bernhard Bader investigates cell biological and molecular mechanisms in adipose tissue biology, blood vessel formation/physiology, liver and placenta function in physiological and pathological (e.g. obesi- ty, gestational diabetes) situations in mice, humans and in vitro. The cell biological and molecular cross-talks between different cell types such as adipocytes, endothelial cells, immune cells and intestinal epithelial cells are examined. Gene knock-out technology and feeding trials are applied for mouse studies. Human tissue samples and cells from our dietary inter- vention studies or women with gestational diabetes are analyzed. In recent years and in ongoing projects, we have been exploring the effects of nutri- tion (high-fat diets, n6- and n3 polyunsaturated fatty acids, methyl donor- rich diets) on cell differentiation and metabolic, inflammatory and vascu- lar processes as well as on gene regulatory mechanisms in liver, adipose tissues and intestine. In order to get better insights into the role of nutri- ents in fetal and metabolic programming and their underlying molecular and epigenetic control mechanisms (DNA methylation, microRNA, histone modifications) in different periods of life, we are analyzing the development, metabolism and physiology of adipose tissues, liver and placenta from fee- ding and intervention studies in mice and humans. Our research aims to gain a better understanding how nutrition contributes to and/or can prevent disease processes. Dr. Bernhard L. Bader Technische Universität München Nutritional Medicine Gregor-Mendel-Str. 2, D-85350 Freising-Weihenstephan www.em-tum.de Selected Publications Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader BL. Metabolic and immunomo- dulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet- induced obese mice. Am J Physiol Endocrinol Metab. 2013, Mar 12. Dahlhoff C, Desmarchelier C, Sailer M, Fürst RW, Haag A, Bader BL, Daniel H. Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. PLoS One. 2013; 8(3): e57387. Hauner H, Much D, Vollhardt C, Brunner S, Sedlmeier EM, Zimmermann A, Schneider KT, Bader BL, Amann-Gassner U. Effect of reducing the n-6:n-3 long-chain PUFA ratio during preg- nancy and lactation on infant adipose tissue growth within the first year of life. Am J Clin Nutr. 2012; 95(2):383. Mack I, BelAiba RS, Djordjevic T, Görlach A, Hauner H, Bader BL. Functional analyses reveal the greater potency of preadipocytes compared to adipoctes as endothelial cell-activator under normoxia, hypoxia and TNF-α exposure. Am J Physiol Endocrin Metab. 2009, 297(3):E375. Research Goals Identification of effects of nutrition and their underlying molecular mechanisms in the development and prevention of obesity and diabetes Gain of better insights into molecular and epigenetic mechanisms in fetal and meta- bolic programming Identification of biomarkers for perinatal/ childhood obesity and gestational diabetes for the development of preventive treatment strategies

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