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GRK 1482 Jahrbuch 2011-2014

SENIOR PRINCIPAL INVESTIGATORS GRK Annual Report 2011-2014 | Page 25 Education / Degrees 1986-1990 Study of Philosophy, History and Modern German Literature (Christiana Albertina, Kiel, Germany) 1990-1995 Study of Medicine (Freie Universität, Berlin, Germany) 1994 USMLE: Basic Sciences 1995 USMLE: Clinical Sciences 1998 MD thesis: Gliadin Binding to Rat and Human Proteins 2004 Habilitation: „Genetic Basis of Chronic Pancreatitis“, Charité Positions held 1995-1998 Institute of Laboratory Medicine and Pathobiochemistry, Charité, Berlin, Germany) 1999-2004 Department of Paediatrics (Charité) Division of Paediatric Gastroenterology and Hepatology 2004-2008 Department of Gastroenterology (Charité) 2008 Qualification as Paediatrician 2008 to date Professor “Paediatric Nutritional Medicine”, Department of Paediatrics & Else Kröner-Fresenius- Zentrum, Technische Universität München Research Interests and Achievements The main research interest of the group of Heiko Witt is genetic epidemio- logy of paediatric gastrointestinal diseases with focus on the molecular basis of pancreatic diseases. The group contributed significantly to the un- derstanding of chronic idiopathic/hereditary pancreatitis as well as to the understanding of chronic alcoholic pancreatitis. So far, several novel genetic factors which are involved in the pathogenesis of idiopathic/hereditary pancreatitis such as SPINK1, anionic trypsinogen (PRSS2) and chymotrypsin C (CTRC) has been identified by the research group and published in Nature Genetics. These studies substantially changed medical thinking by showing that so-called idiopathic pancreatitis represents also an inherited disorder. The identification of the above mentioned genetic factors gave major impact on the field and resulted in numerous genetic and functional stu- dies as well as the generation of genetically engineered animals around the world. The group furthermore showed that defects in the genes mentioned above also contribute to much more common types of pancreatitis i.e. alcoholic or tropical chronic pancreatitis. Thus, studying of rare hereditary pancreatitis might serve as model for other more common entities of the disorder. Other main research interests are the genetics of inflammatory bowel disease, various liver diseasse and currently fructose malabsorption. Prof. Dr. Heiko Witt Technische Universität München Paediatric Nutritional Medicine Gregor-Mendel-Str. 2, D-85350 Freising - Weihenstephan www.em-tum.de Selected Publications Rosendahl J, Landt O, Bernadova J, Kovacs P, Teich N, Bödeker H, Keim V, Ruffert C, Mössner J, Kage A, Stumvoll M, Groneberg D, Krüger R, Luck W, Treiber M, Becker M, Witt H. CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR over- estimated? Gut. 2013, 62:582-92. Neuhöfer P, Liang S, Einwächter H, Schwerdtfeger C, Wartmann T, Treiber M, Zhang H, Schulz HU, Dlubatz K, Lesina M, Diakopoulos KN, Wörmann S, Halangk W, Witt H, Schmid RM, Algül H. Deletion of IκBα activates RelA to reduce acute pancreati- tis in mice through up-regulation of Spi2A. Gastroenterology. 2013,144:192-201. Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M. Comprehensive functio- nal analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk. Gut. 2012 Sep 1. [Epub ahead of print]. Schnúr A, Beer S, Witt H, Hegyi P, Sahin-Tóth M. Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis. Gut. 2013 Mar 1. [Epub ahead of print]. Research Goals Identification of genetic risk factors predis- posing to inherited and alcohol-related chronic pancreatitis Identification of the underlying genetic cau- ses of fructose malabsorption Functional characterisation of these genetic defects associated to fructose malabsorp- tion by cell culture and promotor analyses

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