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GRK 1482 Jahrbuch 2011-2014

SENIOR PRINCIPAL INVESTIGATORS Page 18 | GRK Progress Report 2011-2014 Education / Degrees 1981 - 1987 Biology, Philipps-Universität Marburg, Germany 1987 Diploma in Biology 1994 Ph.D. Animal Physiology (Philipps-Universität Marburg) 2001 Habilitation and venia legendi for Zoology and Animal Physiology (Philipps-Universität Marburg) Positions held 1994 - 1995 Postdoctoral fellow, Department of Animal Physiology, Philipps-Universität Marburg 1995 - 1996 Postdoctoral fellow, Lipid Research Laboratory, West Los Angeles VA Medical Center, USA 1997 - 2001 Assistant Professor for Animal Physiology, Philipps-Universität Marburg 2002 - 2004 Associate Professor for Animal Physiology, Philipps-Universität Marburg 2004 - 2006 Deputy Chair of the Department of Animal Physiology, Philipps-Universität Marburg 2007 - 2011 Professor for Molecular Nutritional Medicine, Else Kröner-Fresenius Endowment Professorship, Technische Universität München 2011 to date Full Professor for Molecular Nutritional Medicine, Else Kröner-Fresenius Endowment Professorship, Technische Universität München Research Interests and Achievements Physiological and genetic adaptations of metabolism tune our body to ade- quately respond to food components and nutritional challenges. Our group investigates the impact of nutrition on the balance between energy intake and energy expenditure in laboratory mice, in cultured cells and in isolated mitochondria. Our research addresses several aspects of nutritional and metabolic physiology. One major focus of our work is the function of classical brown adipose tis- sue and brown adipocytes emerging in white adipose tissue (brite) for the regulation of energy balance. Brown and brite adipocytes are specialized thermogenic cells that utilize mitochondrial uncoupling protein 1 (UCP1) to dissipate proton motive force as heat. With activated UCP1 this unique mechanism directly converts nutrient energy into heat. We aim to identify dietary components that stimulate the recruitment of brown and brite adi- pocytes. On the other hand we investigate the hormones involved in gut-brain signa- ling and energy balance regulation. The central action of several gut hor- mones converges on the melanocortinergic system in the hypothalamus and the brain stem which harbour metabolic sensor neurons. The activity of melanocortin receptors in the brain conveys satiety and increased energy expenditure. Our research scrutinizes the effect of macronutrient composi- tion on the central sensitivity of these melanocortinergic metabolic sensor sytems. Prof. Dr. Martin Klingenspor Technische Universität München Molecular Nutritional Medicine (Chair) Gregor-Mendel-Str. 2, D-85350 Freising-Weihenstephan www.molekulare-ernaehrungsmedizin.de Selected Publications Lasar D, Julius A, Fromme T, Klingenspor M. Browning attenuates murine white adipose tissue expansion during postnatal development. BBA-Molecular and Cell Biology of Lipids. 2013, 30:1388-1981. Bolze F, Rink N, Brumm H, Kühn R, Mocek S, Schwarz AE, Kless C, Biebermann H, Wurst W, Rozman J, Klingenspor M. Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo. Pharmacogenomics J. 2013, 13(1):80-93. Helwig M, Herwig A, Heldmaier G, Barrett P, Mercer JG, Klingenspor M. Photoperiod-depen- dent regulation of carboxypeptidase E affects se- lective processing of neuropeptides in the seaso- nal Siberian hamster. J Neuroendocrinol. 2013, 25(2):190-7. Jastroch M, Hirschberg V, Klingenspor M. Func- tional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncou- pling artefacts and reveals no contribution to basal proton leak. BBA-Bioenergetics. 2012, 1817(9):1660-70. Fromme T, Klingenspor M. Uncoupling protein 1 expression and high fat diets. Am J Physiol Regul Integr Comp Physiol. 2011, 300(1):R1-8. Research Goals Understanding the effects of nutrition on energy balance regulation Identification and analysis of gene functions in the regulation of energy intake, storage and thermogenesis Molecular basis of adipose tissue plasticity Normal physiology and pathophysiology of mitochondria

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