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GRK 1482 Jahrbuch 2011-2014

SUMMARY OF THE 1ST FUNDING PERIOD OF THE GRK Page 10 | GRK Progress Report 2011-2014 *Steck N, *Mueller K, Schemann M and Haller D. Bacterial proteases in IBD and IBS. Gut. 2012, 61:1610 - 1618. (*NS and KM are joint first authors) Krueger D, Foerster M, Mueller K, Zeller F, Slotta-Huspenina J, Donovan J, Grundy D, Schemann M. Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide. Neurogastroenterol Motil. 2010, 22:1224. Alexander Frank Heiseke . . . . . . . . . . . . . . . . . (Schmid, Reindl, Haller) Heiseke AF, Faul A Cl, Lehr HA, Förster I, Schmid R M, Krug A, Reindl W. CCL17 promotes intestinal inflammation in mice and counter- acts regulatory T cell-mediated protection from colitis. Gastroenterology. 2012, 142:335-345. Dominika Kolodziejczak . . . . . . . . . . . . . . . . . . . . . . . . . . .(Daniel, Hauner) Kolodziejczak D, Spanier B, Pais R, Kraiczy J, Stelzl T, Gedrich K, Scherling C, Zietek T, Daniel H. Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/-absorption that protects them from diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2013, PMID 23494121. Stefan Wagner. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . (Schümann, Haller) Wagner SJ, Schmidt A, Effenberger MJ, Gruber L, Danier J, Haller D. Semisynthetic diet ameliorates Crohn‘s disease like ileitis in TNF∆ARE/WT mice through antigen independent mechanism of gluten. Inflamm Bowel Dis. 2013, [Epub ahead of print] doi: 10.1097/ MIB.0b013e31828f573. Werner T, Wagner SJ, Martínez I, Walter J, Chang JS, Clavel T, Kisling S, Schuemann K, Haller D. Depletion of luminal iron alters the gut microbiota and prevents Crohn´s disease-like ileitis. Gut. 2011, 60: 325-333. Schümann K, Becker C, Wagner SJ, Windisch W. Eisen. In Praxishandbuch Functional Food. Erbersdobler HF, Mayer AH, Hrgb, Behr’s Verlag, 2011:1-39. Werner T, Wagner SJ, Haller D. Die Bedeutung von Eisen bei chronisch entzündlichen Darmer- krankungen. Bauchredner. 1/2010. Tobias Bauer. . . . . . . . . . . . . . . . . (Scherer/Ehling-Schulz/Schemann) Bauer T, Stark T, Hofmann T, Ehling-Schulz M. Development of a stable isotope dilution analysis for the quanti- fication of the Bacillus cereus toxin cereulide in foods. J Agric Food Chem. 2010, 58: 1420-1428. Tobias Ludwig . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .(Hauner, Daniel) Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader BL. Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet- induced obese mice. Am J Physiol Endocrinol Metab. 2013, accepted for publication. Desmarchelier C, Ludwig T, Scheundel R, Rink N, Bader BL, Klingenspor M, Daniel H. Diet-induced obesity in ad libitum-fed mice: food texture overri- des the effect of macronutrient composition. Br J Nutr. 2012, 6:1-10. Publications of associated PhD fellows Emanuel Berger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . (Haller, Schmöller) Chang J-S, Ocvirk S, Berger E, Kisling S, Binder U, Skerra A, Lee AS, Haller D. Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8αβ+ intraepithelial lymphocytes in a mouse model for Crohn´s disease-like ileitis. J Immunol. 2012 Aug 1;189(3):1510-20. Berger E, Haller D. Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endo-plasmic reticulum stress in intestinal epi- thelial cells. Biochem Biophys Res Commun. 2011, 409: 610-615. *Rath E, *Berger E, Messlik A, Nunes T, Liu B, Kim SC, Hoggen- raad N, Sans M, Sator RB, Haller D. Induction of dsRNA-activated protein kinase links mitochond- rial unfolded protein response to the pathogenesis of intestinal inflammation. Gut. 2012, 61:1269-78. Thomas Berger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . (Schemann, Michel) Buhner S, Li Q, Berger T, Vignali S, Barbara G, De Giorgio R, Stanghellini V, Schemann M. Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients. Neurogastroenterol Motil. 2012 Dec;24(12):1134-e572. doi: 10.1111/nmo.12011. Epub 2012 Sep 10. Summary of the 1st Funding Period of the GRK

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